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Percocet: Uses, Dosage, Side Effects, Warnings & FAQ

Percocet (PUR-kuh-set)

Percocet® is a prescription medication that combines oxycodone, a potent opioid pain reliever, with acetaminophen (paracetamol), a non-opioid analgesic and fever reducer. It is commonly prescribed for the short-term treatment of moderate to severe pain when non-opioid pain medicines alone are not sufficient. Because Percocet contains an opioid, it carries serious risks including addiction, misuse, respiratory depression, overdose, liver damage (from acetaminophen), and death if not taken exactly as prescribed.

Pronunciation

Percocet – PUR-kuh-set

Generic Name

Oxycodone hydrochloride / Acetaminophen

Brand Names

Percocet®
Endocet®
Primlev®
Roxicet®
Generic oxycodone/acetaminophen

Availability may vary depending on your country.

Dosage Forms

Percocet is available as:

Oral tablets
Oral solution (generic formulations)

Common tablet strengths include:

Oxycodone	Acetaminophen
2.5 mg	325 mg
5 mg	325 mg
7.5 mg	325 mg
10 mg	325 mg

Some countries or manufacturers may offer additional strengths.

Drug Class

Opioid analgesic combination
Narcotic pain reliever
Combination analgesic
Central nervous system (CNS) depressant

What Is Percocet?

Percocet combines oxycodone, which changes how the brain responds to pain, with acetaminophen, which helps reduce pain and fever through a different mechanism. The combination is often more effective for certain types of pain than either medication alone.

Percocet is generally prescribed for short-term use after surgery, injuries, dental procedures, or other conditions causing moderate to severe pain.

What Is Percocet FDA-Approved For?

Percocet is FDA-approved for the management of:

Moderate to severe pain requiring an opioid analgesic when alternative treatments are inadequate.

It is not intended for long-term use unless specifically directed and monitored by a healthcare provider.

Boxed Warnings

Percocet carries FDA boxed warnings for:

Addiction, abuse, and misuse
Life-threatening respiratory depression
Accidental ingestion
Neonatal opioid withdrawal syndrome during pregnancy
Serious risks when combined with benzodiazepines or other CNS depressants
Severe liver injury from excessive acetaminophen intake

Important Information

Before taking Percocet:

Take exactly as prescribed.
Never take more tablets than directed.
Avoid other medicines containing acetaminophen unless advised by your healthcare provider.
Do not drink alcohol.
Never share your medication.
Store securely away from children and others.

Taking too much acetaminophen can cause severe liver damage, even if you feel well initially.

Before Taking This Medicine

Tell your healthcare provider if you have:

Liver disease
Kidney disease
Asthma
COPD
Sleep apnea
Head injury
Seizure disorder
Heart disease
Low blood pressure
Gallbladder disease
History of alcohol misuse
History of substance use disorder
Depression or other mental health conditions
Pregnancy or plans to become pregnant
Breastfeeding

Also provide a complete list of all prescription medications, over-the-counter medicines, vitamins, and supplements you take.

How Should I Take Percocet?

Take Percocet exactly as prescribed.

General recommendations:

Swallow tablets with water.
May be taken with food if stomach upset occurs.
Do not exceed the prescribed dose.
Follow the dosing schedule provided by your healthcare provider.
If used for more than a short period, do not stop abruptly without medical guidance.

Dosing Information

The appropriate dose depends on:

Pain severity
Previous opioid exposure
Age
Liver and kidney function
Other medical conditions

Healthcare providers prescribe the lowest effective dose for the shortest appropriate duration.

Keep an Opioid Overdose Rescue Medicine on Hand

People taking opioid medications like Percocet may be advised to have naloxone available.

Family members and caregivers should know:

How to recognize an opioid overdose
How to administer naloxone
To call emergency medical services immediately

What Happens If I Miss a Dose?

Percocet is often taken as needed for pain.

If prescribed on a schedule:

Take the missed dose when remembered unless it is almost time for the next dose.
Skip the missed dose if your next dose is due soon.
Never double your dose.

What Happens If I Overdose?

A Percocet overdose is a medical emergency.

Symptoms may include:

Slow or stopped breathing
Extreme drowsiness
Pinpoint pupils
Blue lips or fingernails
Cold, clammy skin
Confusion
Loss of consciousness
Coma

Acetaminophen overdose may also cause delayed but severe liver injury. Seek emergency medical care immediately, even if symptoms seem mild.

What Should I Avoid While Taking Percocet?

Avoid:

Alcohol
Benzodiazepines unless prescribed
Sleeping pills
Muscle relaxants
Recreational drugs
Driving or operating machinery until you know how Percocet affects you
Taking other medications containing acetaminophen without medical advice

Percocet Side Effects

Common Side Effects

Constipation
Nausea
Vomiting
Drowsiness
Dizziness
Headache
Dry mouth
Sweating
Itching
Fatigue

Serious Side Effects

Seek emergency medical attention if you experience:

Difficulty breathing
Severe allergic reaction
Severe skin rash
Yellowing of the skin or eyes
Severe confusion
Hallucinations
Seizures
Chest pain
Loss of consciousness

What Other Drugs Will Affect Percocet?

Percocet may interact with:

Benzodiazepines
Other opioid medications
Alcohol
Sleeping medications
Muscle relaxants
Certain antidepressants
Sedating antihistamines
Certain antibiotics
Certain antifungal medications
Medications containing acetaminophen

Always inform your healthcare provider about all medications you use.

Storage

Store Percocet:

At room temperature
Away from heat and moisture
In a secure, locked location
Out of reach of children and pets

Dispose of unused medication through an approved medication take-back program.

Frequently Asked Questions

What Is Percocet Used For?

Percocet is used to treat moderate to severe pain when non-opioid medications alone are not effective.

Is Percocet an Opioid?

Percocet contains oxycodone, which is an opioid. It also contains acetaminophen, a non-opioid pain reliever.

Is Percocet a Controlled Substance?

Yes.

Percocet is classified as a Schedule II controlled substance in the United States because it contains oxycodone, which has a high potential for misuse and dependence.

How Long Does Percocet Take to Work?

Percocet typically begins relieving pain within 20 to 30 minutes, with peak effects occurring in approximately 1 hour. Pain relief generally lasts 4 to 6 hours.

How Long Does Percocet Stay in Your System?

The detection window depends on the type of drug test and individual factors such as metabolism, dose, and frequency of use.

Approximate detection times:

Urine: 2–4 days
Blood: Up to 24 hours
Saliva: 1–2 days
Hair: Up to 90 days

Vicodin vs. Percocet – What’s the Difference?

Both medications combine an opioid with acetaminophen, but they contain different opioids.

Percocet

Oxycodone + acetaminophen
Often considered more potent on a milligram-to-milligram basis
Used for moderate to severe pain

Vicodin

Hydrocodone + acetaminophen
Also used for moderate to severe pain
Available in different strengths

The most appropriate option depends on the patient’s condition and healthcare provider’s recommendation.

Percocet vs. Oxycodone

Percocet

Contains oxycodone and acetaminophen
Provides combined pain-relieving effects

Oxycodone

Contains only oxycodone
Available in immediate-release and extended-release formulations
Does not contain acetaminophen

Percocet vs. Norco

Percocet

Oxycodone + acetaminophen

Norco

Hydrocodone + acetaminophen

Both are commonly prescribed opioid combination medications for moderate to severe pain. The choice depends on individual response, medical history, and clinician judgment.

Percocet vs. Tylenol

Tylenol (acetaminophen) contains only acetaminophen and does not contain an opioid.

Percocet contains acetaminophen plus oxycodone, making it substantially stronger for pain relief but also associated with greater risks such as dependence and respiratory depression.

Percocet vs. Ibuprofen

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used for pain, inflammation, and fever.

Percocet contains an opioid and is generally reserved for pain that is not adequately controlled with medications such as ibuprofen or acetaminophen alone.

Is Percocet Stronger Than Hydrocodone?

Because Percocet contains oxycodone, it is generally considered more potent on a milligram-to-milligram basis than hydrocodone. However, the overall effectiveness and safety depend on the prescribed dose and the individual’s clinical situation.

Does Percocet Cause Constipation?

Yes.

Constipation is one of the most common side effects of opioid medications. Preventive measures may include adequate hydration, dietary fiber, physical activity when appropriate, and treatment recommended by your healthcare provider.

Which Drugs Cause Opioid-Induced Constipation?

Most opioid medications can cause opioid-induced constipation (OIC), including:

Percocet
Oxycodone
Hydrocodone
Morphine
Hydromorphone
Oxymorphone
Methadone
Fentanyl
Codeine

What Drugs Cause Pinpoint Pupils?

Pinpoint pupils (miosis) are commonly associated with opioid medications, including:

Oxycodone
Percocet
Hydrocodone
Morphine
Hydromorphone
Oxymorphone
Methadone
Fentanyl
Codeine

If pinpoint pupils occur with slowed breathing or reduced responsiveness, seek emergency medical care immediately.

Is Percocet Addictive?

Yes.

Because Percocet contains oxycodone, it carries a significant risk of misuse, addiction, and physical dependence. Taking it only as prescribed helps reduce these risks.

What Are the Withdrawal Symptoms of Percocet?

Stopping Percocet suddenly after prolonged use may lead to opioid withdrawal symptoms such as:

Anxiety
Restlessness
Sweating
Muscle aches
Chills
Yawning
Runny nose
Insomnia
Nausea
Vomiting
Diarrhea
Dilated pupils

A healthcare provider may recommend gradually reducing the dose to minimize withdrawal symptoms.

Can You Drink Alcohol While Taking Percocet?

No.

Alcohol can greatly increase the risk of severe sedation, respiratory depression, liver injury, overdose, and death.

Can Percocet Damage the Liver?

Yes, if taken in excessive amounts or together with other acetaminophen-containing products. High doses of acetaminophen can cause serious liver damage, which may be life-threatening.

Can Percocet Be Taken With Food?

Yes.

Percocet may be taken with or without food. Taking it with food may help reduce nausea in some people.

Does Percocet Make You Sleepy?

Yes.

Drowsiness is a common side effect, particularly when starting treatment or after a dose increase.

Can You Drive While Taking Percocet?

Percocet can impair alertness, coordination, and reaction time. Avoid driving or operating heavy machinery until you know how the medication affects you and your healthcare provider advises it is safe.

Can Percocet Be Used During Pregnancy?

Long-term opioid use during pregnancy may result in neonatal opioid withdrawal syndrome (NOWS). Treatment decisions during pregnancy should always involve a careful discussion with a healthcare provider about the potential benefits and risks.

Final Thoughts

Percocet is a combination medication containing oxycodone and acetaminophen that is used to manage moderate to severe pain when other treatments are not sufficient. While it can provide effective pain relief, it also carries important risks, including addiction, respiratory depression, overdose, constipation, and liver damage from acetaminophen if used improperly. Taking Percocet exactly as prescribed, avoiding alcohol and unnecessary sedating medications, monitoring total acetaminophen intake, storing it securely, and attending regular medical follow-up are essential steps to maximize its benefits while minimizing the risk of serious complications.